THBD

Across TCGA pan-cancer cohorts, THBD RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated THBD data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher THBD RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated THBD expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, MESO, and KIRC are the cancer types where THBD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.321	0.859	<.001	50	view →
MESO	OS	Median	All	0.437	0.646	.001	46	view →
KIRC	DFS	Tertile	All	0.882	0.692	<.001	41	view →
THCA	OS	Median	II,III,IV	0.926	1.000	.006	40	view →
UCS	OS	Median	IV	0.752	0.404	.013	36	view →
LGG	DFS	Median	All	0.338	0.475	<.001	29	view →
ACC	DFS	Median	III,IV	0.221	0.656	<.001	21	view →
SARC	OS	Quartile	All	0.917	0.708	<.001	13	view →
LUAD	DFS	Quartile	II,III,IV	0.361	0.611	.022	13	view →
BRCA	OS	Tertile	III,IV	0.884	0.746	.010	12	view →
KIRP	DFS	Median	II,III,IV	0.559	0.914	.035	10	view →
CHOL	DFS	Median	All	0.608	0.223	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

THBD–UVM (DFS)

Open the UVM breakdown →