THAP7-AS1

Across TCGA patient cohorts, THAP7-AS1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP7-AS1-associated genes across cancer lineages are eEF2, A-Raf_pS299, and ERK2. Each is linked with THAP7-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP7-AS1-to-partner and partner-to-THAP7-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by THAP7-AS1-low versus THAP7-AS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP7-AS1→partner) and Y-score (partner→THAP7-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.366	+1.807	.013	.027	3	1
UCEC	A-Raf_pS299 →	-0.138	-3.321	.005	.010	3	1
UCEC	ERK2 →	+0.227	+3.321	.004	.009	3	1
UCEC	FoxM1 →	+0.223	+2.321	.037	.006	3	1
UCEC	G6PD →	-0.281	-3.156	.035	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.484	+1.807	.021	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eEF2 by THAP7-AS1 expression — UCEC

Explore this box plot interactively →