THAP7-AS1

Across TCGA pan-cancer cohorts, THAP7-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of THAP7-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where THAP7-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types THAP7-AS1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, HNSC, and UCEC are the cancer types where THAP7-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THAP7-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.143	<.001	8	view →
HNSC	All	All	+0.385	.004	7	view →
UCEC	All	All	−0.713	<.001	6	view →
COAD	Female	All	−0.640	<.001	6	view →
KIRC	All	All	−0.231	.012	6	view →
LUSC	All	All	+0.627	<.001	5	view →
THCA	All	All	−0.418	<.001	5	view →
BRCA	Female	II,III,IV	−0.384	<.001	4	view →
BLCA	Male	IV	−0.765	.030	1	view →
LIHC	All	All	+0.203	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

THAP7-AS1–KICH

Open the KICH breakdown →