THAP6

Across TCGA cell cohorts, THAP6 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THAP6-associated genes across cancer lineages are SPEM3, SERPINA7, and MAS1. Each is linked with THAP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP6-to-partner and partner-to-THAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPEM3 grouped by THAP6-low versus THAP6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP6→partner) and Y-score (partner→THAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPEM3 →	+0.013	+3.347	<.001	.005	3	2
SKIN	SERPINA7 →	+0.017	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	MAS1 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WNT8A →	+0.032	+3.632	<.001	.003	3	1
LARGE_INTESTINE	NME8 →	+0.293	+4.022	<.001	.006	3	1
LUNG_NSCLC_LUAD	ZNF716 →	+0.408	+2.882	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SPEM3 by THAP6 expression — LARGE_INTESTINE

Explore this box plot interactively →