THAP6

Across TCGA pan-cancer cohorts, THAP6 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of THAP6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where THAP6 RNA is repressed in tumor relative to normal tissue. In most cancer types THAP6 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, KIRC, and KIRP are the cancer types where THAP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THAP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.565	<.001	10	view →
KIRC	Male	All	+0.311	<.001	9	view →
KIRP	All	II,III,IV	+0.391	.003	7	view →
LIHC	All	All	+0.322	<.001	5	view →
UCEC	All	All	−0.359	.018	4	view →
CHOL	All	All	+1.006	<.001	3	view →
HNSC	All	All	+0.234	.012	3	view →
KICH	All	All	−0.439	.006	2	view →
COAD	Male	All	+0.354	.009	2	view →
ESCA	Female	All	+0.519	.019	1	view →
LUAD	All	All	+0.179	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

THAP6–THCA

Open the THCA breakdown →