TGFBRAP1

Across TCGA patient cohorts, TGFBRAP1 mutation is significantly associated with the RNA expression of many other genes, with 2,860 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFBRAP1-associated genes across cancer lineages are VARS2, RNU1-6P, and TRAPPC2L. Each is linked with TGFBRAP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TGFBRAP1-to-partner and partner-to-TGFBRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VARS2 grouped by TGFBRAP1-low versus TGFBRAP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBRAP1→partner) and Y-score (partner→TGFBRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	VARS2 →	+0.470	+2.366	.001	.003	3	4
LIHC	RNU1-6P →	+0.438	+5.169	<.001	.002	3	3
UCEC	TRAPPC2L →	+0.444	+1.882	<.001	<.001	3	3
SKCM	PGAM1 →	+0.646	+2.353	<.001	.003	3	3
SKCM	KLC2 →	+0.520	+3.233	.004	.008	3	3
SKCM	POLR2A →	+0.585	+2.341	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,860 associations by consensus.

VARS2 by TGFBRAP1 expression — SKCM

Explore this box plot interactively →