TGFBR1

Across TCGA cell cohorts, TGFBR1 mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGFBR1-associated genes across cancer lineages are TMEM252, GCAT, and TRPA1. Each is linked with TGFBR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFBR1-to-partner and partner-to-TGFBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM252 grouped by TGFBR1-low versus TGFBR1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBR1→partner) and Y-score (partner→TGFBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TMEM252 →	+0.039	+3.807	<.001	.003	3	1
LARGE_INTESTINE	GCAT →	+1.378	+3.364	<.001	.002	3	1
LARGE_INTESTINE	TRPA1 →	+0.473	+2.559	<.001	.007	3	1
LARGE_INTESTINE	ZNF330 →	+0.495	+3.364	.004	.002	3	1
LARGE_INTESTINE	MSGN1 →	+0.049	+2.538	.002	.005	3	1
LARGE_INTESTINE	ATP5F1A →	+0.856	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

TMEM252 by TGFBR1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →