TGFBR1

Across TCGA pan-cancer cohorts, TGFBR1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TGFBR1 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TGFBR1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TGFBR1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

ACC, MESO, and BLCA are the cancer types where TGFBR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.214	0.651	<.001	120	view →
MESO	OS	Median	All	0.275	0.485	<.001	84	view →
BLCA	DFS	Median	All	0.161	0.516	<.001	79	view →
LGG	OS	Median	All	0.737	0.887	<.001	53	view →
KIRC	DFS	Tertile	All	0.854	0.684	.001	42	view →
STAD	OS	Tertile	II,III,IV	0.225	0.529	.009	35	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	30	view →
CESC	DFS	Tertile	All	0.734	0.894	.001	26	view →
HNSC	OS	Quartile	III,IV	0.269	0.598	.002	23	view →
SCLC	DFS	Quartile	All	0.553	0.186	<.001	22	view →
LIHC	DFS	Quartile	All	0.198	0.491	.013	13	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TGFBR1–ACC (DFS)

Open the ACC breakdown →