TGFBR1

Across TCGA pan-cancer cohorts, TGFBR1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TGFBR1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TGFBR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TGFBR1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where TGFBR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGFBR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.557	<.001	12	view →
THCA	Male	III,IV	+1.678	<.001	10	view →
LIHC	Female	II,III,IV	+1.091	<.001	8	view →
COAD	Male	All	+0.409	.010	6	view →
CHOL	All	All	+1.371	<.001	4	view →
READ	Male	All	+0.746	.002	4	view →
KICH	All	All	−0.675	.004	4	view →
UCEC	All	All	−0.610	.020	2	view →
LUAD	Male	All	+0.506	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TGFBR1–HNSC

Open the HNSC breakdown →