TFE3

Across TCGA cell cohorts, TFE3 mutation is significantly associated with the mutation status of many other genes, with 1,462 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFE3-associated genes across cancer lineages are KCNMA1, SMPD3, and TRPS1. Each is linked with TFE3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TFE3-to-partner and partner-to-TFE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNMA1 grouped by TFE3-low versus TFE3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFE3→partner) and Y-score (partner→TFE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCNMA1 →	+2.070	+2.807	.002	.002	1	4
SKIN	SMPD3 →	+4.392	+4.392	.009	.009	1	3
BLOOD_Leukemia	TRPS1 →	+2.787	+3.962	<.001	<.001	1	3
SKIN	PCDHB6 →	+2.977	+4.392	.005	.005	1	3
SKIN	PLEKHG3 →	+5.392	+4.824	.004	.004	1	3
SKIN	SCYL1 →	+4.392	+4.392	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,462 associations by consensus.

KCNMA1 by TFE3 expression — LARGE_INTESTINE

Explore this box plot interactively →