TFE3

Across TCGA pan-cancer cohorts, TFE3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TFE3 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TFE3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TFE3 expression acts as an unfavorable survival marker, although some lineages such as ACC and SKCM show a favorable association.

KIRP, UVM, and LIHC are the cancer types where TFE3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.828	0.969	.001	61	view →
UVM	DFS	Median	II,III,IV	0.393	0.743	.002	60	view →
LIHC	DFS	Median	All	0.470	0.607	<.001	59	view →
COAD	DFS	Quartile	All	0.740	0.868	.001	40	view →
ACC	DFS	Median	III,IV	0.585	0.109	.003	39	view →
LGG	OS	Median	All	0.348	0.518	<.001	36	view →
LUSC	DFS	Quartile	III,IV	0.243	1.000	.001	33	view →
LAML	DFS	Quartile	All	0.269	0.530	.004	24	view →
SKCM	OS	Tertile	All	0.854	0.733	.004	23	view →
SCLC	OS	Median	III,IV	0.754	0.462	.023	22	view →
KICH	OS	Quartile	II,III,IV	0.724	1.000	.019	20	view →
LUAD	DFS	Tertile	All	0.740	0.835	.005	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TFE3–KIRP (DFS)

Open the KIRP breakdown →