TFB1M

Across TCGA patient cohorts, TFB1M mutation is significantly associated with the RNA expression of many other genes, with 617 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFB1M-associated genes across cancer lineages are HMGB3P23, SNORA70J, and RPS29P32. Each is linked with TFB1M in more than 2 cancer types. Because this analysis shows association rather than direction, both TFB1M-to-partner and partner-to-TFB1M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB3P23 grouped by TFB1M-low versus TFB1M-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFB1M→partner) and Y-score (partner→TFB1M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HMGB3P23 →	+0.057	+5.327	<.001	.002	3	3
BLCA	SNORA70J →	+1.028	+3.830	<.001	.009	3	2
UCEC	RPS29P32 →	+0.456	+2.462	<.001	.004	3	2
READ	NPLP1 →	+0.291	+5.421	<.001	.005	3	2
LUAD	RNU1-62P →	+0.152	+4.730	<.001	.005	3	2
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 617 associations by consensus.

HMGB3P23 by TFB1M expression — LUAD

Explore this box plot interactively →