TFB1M

Across TCGA pan-cancer cohorts, TFB1M RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TFB1M data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TFB1M RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TFB1M expression acts as an unfavorable survival marker, although some lineages such as READ and SCLC show a favorable association.

OV, LGG, and READ are the cancer types where TFB1M RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	III,IV	0.458	0.605	.001	74	view →
LGG	OS	Median	All	0.745	0.880	<.001	48	view →
READ	DFS	Tertile	All	0.908	0.561	<.001	43	view →
SCLC	DFS	Median	II,III,IV	0.617	0.307	.002	37	view →
LIHC	DFS	Quartile	All	0.447	0.611	.002	34	view →
THCA	DFS	Quartile	All	0.929	0.731	<.001	31	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	23	view →
ACC	DFS	Quartile	All	0.240	0.593	.008	21	view →
COAD	OS	Tertile	All	0.925	0.778	.008	14	view →
STAD	DFS	Median	IV	0.203	0.568	.011	12	view →
KIRP	OS	Median	III,IV	0.521	0.822	.012	12	view →
BRCA	OS	Tertile	All	0.509	0.665	.024	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TFB1M–OV (DFS)

Open the OV breakdown →