Across TCGA pan-cancer cohorts, TEX51 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TEX51’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TEX51 RNA is repressed in tumor relative to normal tissue. In most cancer types TEX51 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.
KIRP and KICH are the cancer types where TEX51 tumor–normal differential expression is most reproducible.