TEX11

Across TCGA patient cohorts, TEX11 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEX11-associated genes across cancer lineages are VHL, p21, and P-Cadherin. Each is linked with TEX11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEX11-to-partner and partner-to-TEX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by TEX11-low versus TEX11-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEX11→partner) and Y-score (partner→TEX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VHL →	-1.394	-3.000	.003	.035	3	2
UCEC	p21 →	+0.122	+2.321	.047	.005	3	2
UCEC	P-Cadherin →	-0.122	-2.584	.007	.010	3	2
UCEC	SETD2 →	-0.139	-1.289	.046	.023	3	2
UCEC	ARID1A →	-0.121	-1.385	.044	.019	3	2
UCEC	STAT3_pY705 →	-0.307	-1.352	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

VHL by TEX11 expression — LUAD

Explore this box plot interactively →