Q-omics provides the consensus-scored TESC-AS1 profile across patient tissues and cancer cell-line models. TESC-AS1 expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, TESC-AS1 is differentially expressed in 11, with the highest sampling consensus in COAD. Additionally, TESC-AS1 RNA expression shows 10,678 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight LUAD, COAD, and KIRP as cancer lineages where TESC-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TESC-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TESC-AS1 survival associations across molecular data types. TESC-AS1 RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TESC-AS1 RNA expression–survival associations across cancer types. High TESC-AS1 expression shows unfavorable associations in LUAD, LUSC, OV, READ and THYM, but favorable associations in UCEC. The LUAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUAD as the clearest survival context for TESC-AS1 RNA expression.
This table summarizes TESC-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for TESC-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TESC-AS1 shows lower tumor expression in KICH and higher tumor expression in COAD, READ, CHOL, STAD and LUAD. The COAD box plot shows higher TESC-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.139, t-test p < 0.001).
This table shows molecular features associated with TESC-AS1 in patient tissues and cancer cell lines. In patient samples, TESC-AS1 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set.
