TESC-AS1

Across TCGA pan-cancer cohorts, TESC-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated TESC-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TESC-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TESC-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRC show a favorable association.

LUAD, LUSC, and OV are the cancer types where TESC-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.709	0.838	<.001	66	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	48	view →
OV	OS	Quartile	III,IV	0.233	0.359	.009	42	view →
READ	DFS	Tertile	II,III,IV	0.668	0.885	.001	31	view →
UCEC	DFS	Median	IV	0.888	0.499	.002	28	view →
THYM	DFS	Quartile	II,III,IV	0.442	0.852	.010	27	view →
KIRC	OS	Median	All	0.844	0.767	.003	23	view →
ESCA	OS	Tertile	All	0.546	1.000	.011	18	view →
CHOL	OS	Median	All	0.179	0.888	.003	11	view →
KICH	DFS	Median	II,III,IV	0.656	0.943	.038	5	view →
MESO	OS	Quartile	III,IV	0.757	0.539	.022	4	view →
SKCM	DFS	Quartile	All	0.287	0.177	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

TESC-AS1–LUAD (DFS)

Open the LUAD breakdown →