TERF1

Across TCGA cell cohorts, TERF1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TERF1-associated genes across cancer lineages are GAD2, PRSS54, and ZNF831. Each is linked with TERF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TERF1-to-partner and partner-to-TERF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAD2 grouped by TERF1-low versus TERF1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TERF1→partner) and Y-score (partner→TERF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GAD2 →	+0.029	+4.523	<.001	.004	3	1
LARGE_INTESTINE	PRSS54 →	+0.034	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	ZNF831 →	+0.011	+3.103	<.001	.004	3	1
LARGE_INTESTINE	DEUP1 →	+0.356	+3.569	<.001	.006	3	1
LARGE_INTESTINE	IL27 →	+0.392	+3.716	<.001	.003	3	1
LARGE_INTESTINE	FABP12 →	+0.041	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GAD2 by TERF1 expression — BLOOD_Lymphoma

Explore this box plot interactively →