TEPP

Across TCGA cell cohorts, TEPP mutation is significantly associated with the drug of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TEPP-associated genes across cancer lineages are Afuresertib, AZD5363, and Ipatasertib. Each is linked with TEPP in more than 1 cancer types. Because this analysis shows association rather than direction, both TEPP-to-partner and partner-to-TEPP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Afuresertib grouped by TEPP-low versus TEPP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEPP→partner) and Y-score (partner→TEPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Afuresertib →	+0.545	+2.871	.042	.021	3	1
LARGE_INTESTINE	AZD5363 →	+0.529	+2.871	.045	.021	3	1
LARGE_INTESTINE	Ipatasertib →	+0.521	+2.871	.044	.021	3	1
LARGE_INTESTINE	QL-XII-61 →	+0.487	+2.672	.005	.039	2	1
LARGE_INTESTINE	UNC1215 →	+0.192	+2.938	.048	.019	2	1
LARGE_INTESTINE	GSK2276186C →	+0.429	+3.064	.041	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Afuresertib by TEPP expression — LARGE_INTESTINE

Explore this box plot interactively →