TEPP

Across TCGA pan-cancer cohorts, TEPP RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TEPP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TEPP RNA is repressed in tumor relative to normal tissue. In most cancer types TEPP is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and BRCA are the cancer types where TEPP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TEPP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.662	<.001	9	view →
KIRC	Male	II,III,IV	−0.192	<.001	7	view →
BRCA	Female	II,III,IV	−0.958	<.001	6	view →
UCEC	All	All	−0.825	<.001	6	view →
LUAD	Male	II,III,IV	−0.813	<.001	6	view →
COAD	All	II,III,IV	−0.072	<.001	6	view →
LUSC	Female	All	−0.837	<.001	5	view →
HNSC	All	II,III,IV	−0.262	.008	5	view →
STAD	All	II,III,IV	−0.172	.022	3	view →
READ	All	All	−0.117	.004	3	view →
BLCA	All	IV	+1.608	.011	2	view →
PRAD	All	All	−0.647	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TEPP–KICH

Open the KICH breakdown →