TENT5C

Across TCGA patient cohorts, TENT5C mutation is significantly associated with the RNA expression of many other genes, with 3,733 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENT5C-associated genes across cancer lineages are SFPQP1, ZWINT, and CDCA5. Each is linked with TENT5C in more than 3 cancer types. Because this analysis shows association rather than direction, both TENT5C-to-partner and partner-to-TENT5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFPQP1 grouped by TENT5C-low versus TENT5C-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT5C→partner) and Y-score (partner→TENT5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SFPQP1 →	+0.046	+4.971	<.001	.005	3	4
UCEC	ZWINT →	+0.768	+2.321	<.001	<.001	3	3
UCEC	CDCA5 →	+0.872	+2.496	<.001	<.001	3	3
UCEC	PKN3 →	+0.912	+3.332	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.596	+1.925	<.001	<.001	3	3
COAD	ZFYVE19 →	+0.331	+2.700	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,733 associations by consensus.

SFPQP1 by TENT5C expression — BRCA

Explore this box plot interactively →