TENT5C

Across TCGA pan-cancer cohorts, TENT5C RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TENT5C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TENT5C RNA is repressed in tumor relative to normal tissue. In most cancer types TENT5C is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KIRC are the cancer types where TENT5C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TENT5C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.635	<.001	11	view →
THCA	Male	All	−1.930	<.001	11	view →
KIRC	Female	All	−0.961	<.001	11	view →
KIRP	All	III,IV	−1.877	<.001	9	view →
KICH	All	All	−1.275	<.001	9	view →
BLCA	All	All	−1.297	<.001	8	view →
LUSC	Male	II,III,IV	−1.862	<.001	6	view →
HNSC	Male	All	−1.051	.004	5	view →
READ	All	All	−2.339	.002	3	view →
PRAD	All	All	−0.437	.006	2	view →
BRCA	All	All	+0.363	.017	2	view →
LIHC	Female	II,III,IV	−0.728	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TENT5C–COAD

Open the COAD breakdown →