TENT5B

Across TCGA patient cohorts, TENT5B mutation is significantly associated with the RNA expression of many other genes, with 3,740 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENT5B-associated genes across cancer lineages are TSEN2P1, PCMTD1P1, and VPS29. Each is linked with TENT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both TENT5B-to-partner and partner-to-TENT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSEN2P1 grouped by TENT5B-low versus TENT5B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT5B→partner) and Y-score (partner→TENT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TSEN2P1 →	+0.038	+6.147	<.001	.002	3	2
LUSC	PCMTD1P1 →	+0.204	+6.733	<.001	<.001	3	2
UCEC	VPS29 →	+0.505	+3.290	<.001	<.001	3	2
UCEC	FAM184A →	+0.443	+2.210	.002	.009	3	2
UCEC	FIG4 →	+0.337	+2.627	.006	.005	3	2
UCEC	SLC25A19 →	+0.476	+3.625	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,740 associations by consensus.

TSEN2P1 by TENT5B expression — BLCA

Explore this box plot interactively →