TENT5B

Across TCGA pan-cancer cohorts, TENT5B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TENT5B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TENT5B RNA is repressed in tumor relative to normal tissue. In most cancer types TENT5B is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

BLCA, KIRC, and THCA are the cancer types where TENT5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TENT5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−4.181	<.001	12	view →
KIRC	Female	II,III,IV	−2.689	<.001	12	view →
THCA	Female	All	−1.795	<.001	10	view →
HNSC	All	III,IV	−1.640	<.001	10	view →
LUAD	Male	III,IV	−3.316	<.001	9	view →
KIRP	Male	II,III,IV	−2.545	<.001	9	view →
COAD	Male	II,III,IV	−1.950	<.001	9	view →
KICH	Male	All	−2.295	<.001	7	view →
LUSC	Female	II,III,IV	−2.450	<.001	6	view →
STAD	All	All	−1.791	.004	5	view →
LIHC	Female	II,III,IV	+0.567	.001	5	view →
READ	All	All	−2.455	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TENT5B–BLCA

Open the BLCA breakdown →