TENT5B

Across TCGA pan-cancer cohorts, TENT5B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TENT5B data layer compared with 5 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TENT5B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TENT5B expression acts as an unfavorable survival marker, although some lineages such as UVM and ACC show a favorable association.

LGG, UVM, and LUSC are the cancer types where TENT5B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.647	0.828	<.001	54	view →
UVM	OS	Median	All	0.942	0.674	.003	51	view →
LUSC	OS	Median	All	0.577	0.731	<.001	36	view →
KICH	OS	Median	III,IV	0.766	1.000	.006	33	view →
MESO	OS	Quartile	All	0.219	0.474	.011	33	view →
ACC	OS	Median	III,IV	0.840	0.155	<.001	32	view →
BLCA	OS	Median	II,III,IV	0.673	0.762	.021	20	view →
READ	OS	Median	All	0.853	0.985	.006	14	view →
LIHC	OS	Quartile	All	0.611	0.839	.002	13	view →
UCS	OS	Median	IV	0.224	0.732	.018	12	view →
LUAD	DFS	Tertile	IV	0.323	0.688	.024	12	view →
SCLC	DFS	Quartile	III,IV	0.678	0.283	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TENT5B–LGG (DFS)

Open the LGG breakdown →