TENT5B

Across TCGA patient cohorts, TENT5B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENT5B-associated genes across cancer lineages are JNK_pT183_Y185, EGFR_pY1068, and ERK2. Each is linked with TENT5B in more than 1 cancer types. Because this analysis shows association rather than direction, both TENT5B-to-partner and partner-to-TENT5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by TENT5B-low versus TENT5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT5B→partner) and Y-score (partner→TENT5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.222	-2.459	.002	.018	3	2
UCEC	EGFR_pY1068 →	-0.253	-2.115	.021	.019	3	1
UCEC	ERK2 →	+0.191	+2.807	.023	.003	3	1
UCEC	Ku80 →	+0.377	+2.820	<.001	.001	3	1
UCEC	MEK1 →	+0.352	+2.459	.027	.019	3	1
UCEC	mTOR_pS2448 →	-0.145	-3.156	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

JNK_pT183_Y185 by TENT5B expression — UCEC

Explore this box plot interactively →