TEN1-CDK3

Across TCGA pan-cancer cohorts, TEN1-CDK3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TEN1-CDK3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TEN1-CDK3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TEN1-CDK3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, ACC, and KIRC are the cancer types where TEN1-CDK3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.793	0.624	<.001	134	view →
ACC	OS	Quartile	All	0.546	0.921	<.001	71	view →
KIRC	DFS	Median	All	0.500	0.702	<.001	67	view →
PAAD	OS	Tertile	All	0.532	0.209	<.001	53	view →
BLCA	OS	Median	All	0.770	0.667	.009	46	view →
COAD	DFS	Quartile	All	0.356	0.707	<.001	39	view →
SKCM	DFS	Quartile	All	0.751	0.602	.002	38	view →
PRAD	DFS	Tertile	All	0.684	0.881	<.001	32	view →
LGG	DFS	Median	All	0.659	0.812	<.001	31	view →
KICH	DFS	Median	All	0.656	1.000	.002	30	view →
UVM	DFS	Quartile	III,IV	0.172	0.813	.003	28	view →
BRCA	OS	Quartile	III,IV	0.812	0.565	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TEN1-CDK3–HNSC (OS)

Open the HNSC breakdown →