TEK

Across TCGA patient cohorts, TEK mutation is significantly associated with the RNA expression of many other genes, with 3,859 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEK-associated genes across cancer lineages are SKA1, TYMS, and ME2. Each is linked with TEK in more than 2 cancer types. Because this analysis shows association rather than direction, both TEK-to-partner and partner-to-TEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by TEK-low versus TEK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEK→partner) and Y-score (partner→TEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SKA1 →	+0.540	+2.713	.006	.003	3	3
UCEC	TYMS →	+0.776	+1.678	<.001	<.001	3	3
UCEC	ME2 →	+0.386	+1.332	.001	.003	3	3
UCEC	RNU1-153P →	-0.632	-2.321	<.001	<.001	3	3
UCEC	SENP3-EIF4A1 →	+0.072	+1.781	.002	.002	3	3
UCEC	GMDS →	+0.534	+1.936	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,859 associations by consensus.

SKA1 by TEK expression — COAD

Explore this box plot interactively →