TEK

Across TCGA pan-cancer cohorts, TEK RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TEK data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TEK RNA is associated with better overall survival. In most high-consensus cancer types, elevated TEK expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, BLCA, and HNSC are the cancer types where TEK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.744	0.518	<.001	184	view →
BLCA	DFS	Median	IV	0.100	0.322	.003	73	view →
HNSC	DFS	Median	IV	0.449	0.232	<.001	71	view →
LIHC	OS	Median	All	0.759	0.612	<.001	56	view →
KIRP	DFS	Median	All	0.785	0.980	.004	50	view →
MESO	OS	Quartile	II,III,IV	0.285	0.612	.002	46	view →
BRCA	DFS	Median	III,IV	0.851	0.731	.005	42	view →
STAD	OS	Quartile	All	0.606	0.860	.007	27	view →
UCEC	OS	Quartile	III,IV	0.724	0.420	.013	26	view →
THCA	DFS	Median	IV	0.877	0.429	<.001	24	view →
UVM	DFS	Median	All	0.436	0.695	.002	24	view →
PCPG	DFS	Tertile	All	1.000	0.640	.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TEK–KIRC (OS)

Open the KIRC breakdown →