TEF

Across TCGA patient cohorts, TEF mutation is significantly associated with the RNA expression of many other genes, with 441 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEF-associated genes across cancer lineages are RNU4-10P, RNA5SP379, and RNU6-99P. Each is linked with TEF in more than 1 cancer types. Because this analysis shows association rather than direction, both TEF-to-partner and partner-to-TEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-10P grouped by TEF-low versus TEF-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEF→partner) and Y-score (partner→TEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU4-10P →	+0.595	+4.917	<.001	.003	3	2
COAD	RNA5SP379 →	+0.710	+3.694	.005	.007	3	2
UCEC	RNU6-99P →	+0.176	+4.890	<.001	.002	3	2
UCEC	RNU2-47P →	+0.136	+4.890	<.001	.002	3	2
UCEC	PABPC1L2B-AS1 →	+0.019	+4.075	<.001	.007	3	2
LGG	CST8 →	+0.049	+5.679	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 441 associations by consensus.

RNU4-10P by TEF expression — COAD

Explore this box plot interactively →