TEF

Across TCGA pan-cancer cohorts, TEF RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TEF’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TEF RNA is repressed in tumor relative to normal tissue. In most cancer types TEF is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, LIHC, and KIRP are the cancer types where TEF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TEF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.687	<.001	12	view →
LIHC	Female	II,III,IV	+1.648	<.001	9	view →
KIRP	Female	All	−1.562	<.001	9	view →
LUAD	Male	II,III,IV	−1.539	<.001	9	view →
BLCA	Male	III,IV	−1.628	<.001	8	view →
KIRC	Male	II,III,IV	−0.841	<.001	7	view →
UCEC	All	All	−2.189	<.001	6	view →
BRCA	All	III,IV	−1.352	<.001	6	view →
STAD	All	All	−0.848	.001	6	view →
READ	All	All	−1.660	<.001	5	view →
KICH	Male	All	−0.882	.016	4	view →
CHOL	All	All	+0.987	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TEF–COAD

Open the COAD breakdown →