TEC

Across TCGA patient cohorts, TEC mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEC-associated genes across cancer lineages are MEK1, PCNA, and Shc_pY317. Each is linked with TEC in more than 1 cancer types. Because this analysis shows association rather than direction, both TEC-to-partner and partner-to-TEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TEC-low versus TEC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEC→partner) and Y-score (partner→TEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.378	+2.247	.004	.001	3	2
UCEC	PCNA →	+0.175	+1.502	.028	.030	3	2
UCEC	Shc_pY317 →	-0.202	-2.906	<.001	.001	3	2
UCEC	ASNS →	+0.442	+1.502	<.001	.030	3	2
UCEC	4E-BP1 →	+0.342	+1.936	<.001	.008	3	2
UCEC	C-Raf →	+0.187	+3.169	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MEK1 by TEC expression — UCEC

Explore this box plot interactively →