TEC

Across TCGA pan-cancer cohorts, TEC RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TEC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TEC RNA is repressed in tumor relative to normal tissue. In most cancer types TEC is over-expressed in tumor, although a few such as HNSC and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where TEC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TEC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.966	<.001	11	view →
KIRC	Male	IV	+0.574	<.001	11	view →
KIRP	All	IV	+0.994	<.001	9	view →
LUSC	Female	All	−1.245	<.001	6	view →
UCEC	All	All	+0.833	.002	6	view →
THCA	Male	All	+0.403	<.001	6	view →
COAD	Male	All	+0.335	.002	4	view →
BRCA	All	II,III,IV	−0.286	<.001	4	view →
CHOL	All	All	+0.516	.013	2	view →
PRAD	All	All	+0.166	.024	2	view →
READ	All	All	+0.425	.031	1	view →
LIHC	Female	All	−0.321	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TEC–HNSC

Open the HNSC breakdown →