TEC

Across TCGA cell cohorts, TEC mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TEC-associated genes across cancer lineages are GUCA2A, LYZL2, and PSG7. Each is linked with TEC in more than 1 cancer types. Because this analysis shows association rather than direction, both TEC-to-partner and partner-to-TEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by TEC-low versus TEC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEC→partner) and Y-score (partner→TEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	2
STOMACH	LYZL2 →	+0.062	+3.432	<.001	.008	3	1
BLOOD_Leukemia	PSG7 →	+0.028	+4.409	.003	.005	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.071	+4.539	<.001	.007	3	1
LUNG_SCLC	CRYGC →	+0.040	+4.643	<.001	.004	3	1
LUNG_SCLC	PNLIPRP1 →	+0.059	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GUCA2A by TEC expression — BLOOD_Leukemia

Explore this box plot interactively →