TDRKH

Across TCGA cell cohorts, TDRKH mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TDRKH-associated genes across cancer lineages are H4C13, SPINK14, and PTH. Each is linked with TDRKH in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRKH-to-partner and partner-to-TDRKH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H4C13 grouped by TDRKH-low versus TDRKH-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRKH→partner) and Y-score (partner→TDRKH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	H4C13 →	+0.340	+3.584	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPINK14 →	+0.267	+4.662	<.001	.005	3	1
BLOOD_Lymphoma	PTH →	+0.013	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	CLEC19A →	+0.145	+3.925	<.001	.005	3	1
LUNG_SCLC	KRTAP12-4 →	+0.060	+4.058	<.001	.007	3	1
LUNG_SCLC	MROH5 →	+0.012	+4.256	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

H4C13 by TDRKH expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →