TDRKH

Across TCGA pan-cancer cohorts, TDRKH RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TDRKH’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TDRKH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TDRKH is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

LUAD, HNSC, and BLCA are the cancer types where TDRKH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TDRKH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.353	<.001	11	view →
HNSC	Female	All	+1.075	<.001	11	view →
BLCA	Male	All	+1.276	<.001	10	view →
KICH	Male	All	−1.209	<.001	10	view →
COAD	Male	IV	+1.158	<.001	10	view →
LIHC	Male	All	+1.516	<.001	9	view →
KIRC	All	II,III,IV	−0.460	<.001	7	view →
UCEC	All	II,III,IV	+1.257	<.001	6	view →
BRCA	All	III,IV	+1.121	<.001	6	view →
STAD	Male	II,III,IV	+1.102	<.001	6	view →
CHOL	Male	All	+2.413	<.001	5	view →
KIRP	All	II,III,IV	+0.581	.018	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TDRKH–LUAD

Open the LUAD breakdown →