TDG

Across TCGA cell cohorts, TDG mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDG-associated genes across cancer lineages are IFITM5, ACTRT1, and WFDC8. Each is linked with TDG in more than 1 cancer types. Because this analysis shows association rather than direction, both TDG-to-partner and partner-to-TDG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFITM5 grouped by TDG-low versus TDG-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDG→partner) and Y-score (partner→TDG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IFITM5 →	+0.103	+3.807	<.001	.007	3	2
OESOPHAGUS	ACTRT1 →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	WFDC8 →	+0.020	+4.906	<.001	.006	3	1
OESOPHAGUS	MS4A12 →	+0.043	+4.906	<.001	.006	3	1
LARGE_INTESTINE	TLX3 →	+0.448	+2.716	<.001	.009	3	1
LARGE_INTESTINE	S100G →	+1.023	+2.688	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IFITM5 by TDG expression — SKIN

Explore this box plot interactively →