TDG

Across TCGA pan-cancer cohorts, TDG RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TDG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TDG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TDG is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and KIRP are the cancer types where TDG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TDG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.973	<.001	12	view →
BLCA	Male	III,IV	+1.508	<.001	11	view →
KIRP	All	All	+0.558	<.001	11	view →
KIRC	All	IV	+0.549	<.001	11	view →
STAD	All	II,III,IV	+0.980	<.001	9	view →
LUSC	Female	All	+1.240	<.001	8	view →
LIHC	All	II,III,IV	+0.736	<.001	8	view →
LUAD	Male	II,III,IV	+0.836	<.001	7	view →
THCA	All	All	−0.366	<.001	7	view →
UCEC	All	All	+0.786	<.001	6	view →
BRCA	All	III,IV	+0.640	<.001	6	view →
CHOL	Male	All	+1.950	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TDG–HNSC

Open the HNSC breakdown →