TCP1

Across TCGA cell cohorts, TCP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,346 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TCP1-associated GO terms across cancer lineages are DNA replication initiation, Negative regulation of ubiquitin protein ligase activity, and Sister chromatid segregation. Each is linked with TCP1 in more than 18 cancer types. Because this analysis shows association rather than direction, both TCP1-to-partner and partner-to-TCP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by TCP1-low versus TCP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP1→partner) and Y-score (partner→TCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication initiation →	+0.160	+0.681	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Negative regulation of ubiquitin protein ligase activity →	+0.258	+1.301	<.001	<.001	3	18
KIDNEY	Sister chromatid segregation →	+0.125	+1.035	<.001	<.001	3	18
KIDNEY	Nuclear chromosome segregation →	+0.131	+1.066	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Mitotic nuclear division →	+0.120	+0.910	<.001	.001	3	18
LUNG_SCLC	RNA polymerase I preinitiation complex assembly →	+0.121	+0.900	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,346 associations by consensus.

DNA replication initiation by TCP1 expression — BONE

Explore this box plot interactively →