TCP1

Across TCGA pan-cancer cohorts, TCP1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TCP1 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TCP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TCP1 expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

LIHC, MESO, and KIRP are the cancer types where TCP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.587	0.785	<.001	101	view →
MESO	OS	Tertile	All	0.389	0.696	.001	85	view →
KIRP	DFS	Tertile	All	0.855	0.976	<.001	83	view →
BRCA	OS	Median	All	0.502	0.660	<.001	61	view →
LUAD	DFS	Median	IV	0.469	0.892	<.001	60	view →
ESCA	OS	Median	All	0.540	0.785	<.001	57	view →
ACC	OS	Tertile	II,III,IV	0.754	0.971	<.001	52	view →
READ	DFS	Tertile	II,III,IV	0.706	0.270	.006	45	view →
OV	DFS	Quartile	III,IV	0.459	0.582	.020	44	view →
HNSC	OS	Quartile	All	0.569	0.873	<.001	36	view →
CESC	OS	Quartile	All	0.712	0.883	.005	28	view →
KICH	DFS	Median	II,III,IV	0.524	0.926	.001	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TCP1–LIHC (OS)

Open the LIHC breakdown →