TCP1

Across TCGA pan-cancer cohorts, TCP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TCP1’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where TCP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TCP1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

STAD, LIHC, and COAD are the cancer types where TCP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TCP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	II,III,IV	+0.884	<.001	9	view →
LIHC	All	II,III,IV	+0.834	<.001	9	view →
COAD	Female	II,III,IV	+0.645	<.001	9	view →
BLCA	All	III,IV	+0.497	.001	9	view →
LUSC	Male	II,III,IV	+1.150	<.001	8	view →
HNSC	Male	IV	+0.922	<.001	8	view →
LUAD	Male	II,III,IV	+0.616	<.001	8	view →
KICH	Female	II,III,IV	−1.377	<.001	7	view →
THCA	All	All	−0.287	<.001	7	view →
CHOL	All	All	+1.718	<.001	5	view →
READ	All	III,IV	+1.445	.016	2	view →
PRAD	All	All	+0.416	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TCP1–STAD

Open the STAD breakdown →