TCP1

Across TCGA cell cohorts, TCP1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCP1-associated genes across cancer lineages are MYH8, TBR1, and NDUFC2. Each is linked with TCP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCP1-to-partner and partner-to-TCP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH8 grouped by TCP1-low versus TCP1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCP1→partner) and Y-score (partner→TCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MYH8 →	+0.042	+3.716	<.001	.008	3	1
LARGE_INTESTINE	TBR1 →	+0.034	+2.748	<.001	.004	3	1
LARGE_INTESTINE	NDUFC2 →	-0.752	-3.105	.001	.009	3	1
LARGE_INTESTINE	LBHD1 →	+0.771	+3.212	.002	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.014	+2.559	.008	.003	3	1
LARGE_INTESTINE	PXT1 →	+0.034	+3.237	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MYH8 by TCP1 expression — SKIN

Explore this box plot interactively →