TCF24

Across TCGA cell cohorts, TCF24 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TCF24-associated genes across cancer lineages are TEX33, DEFA3, and FOXB2. Each is linked with TCF24 in more than 1 cancer types. Because this analysis shows association rather than direction, both TCF24-to-partner and partner-to-TCF24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX33 grouped by TCF24-low versus TCF24-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TCF24→partner) and Y-score (partner→TCF24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TEX33 →	+0.035	+4.467	.002	.004	3	1
LARGE_INTESTINE	DEFA3 →	+0.076	+4.415	<.001	.007	3	1
OVARY	FOXB2 →	+0.036	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TEX33 by TCF24 expression — LARGE_INTESTINE

Explore this box plot interactively →