TBXT

Across TCGA patient cohorts, TBXT RNA expression is significantly associated with the go_rna of many other GO terms, with 6,516 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TBXT-associated GO terms across cancer lineages are Regulation of protein serine/threonine kinase activity, Positive regulation of protein modification by small protein conjugation or removal, and Sister chromatid cohesion. Each is linked with TBXT in more than 12 cancer types. Because this analysis shows association rather than direction, both TBXT-to-partner and partner-to-TBXT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein serine/threonine kinase activity grouped by TBXT-low versus TBXT-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBXT→partner) and Y-score (partner→TBXT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of protein serine/threonine kinase activity →	+0.041	+0.154	<.001	<.001	3	13
STAD	Positive regulation of protein modification by small protein conjugation or removal →	+0.076	+0.241	<.001	<.001	3	11
SCLC	Sister chromatid cohesion →	+0.116	+2.371	<.001	<.001	3	11
STAD	Microtubule polymerization or depolymerization →	+0.041	+0.153	<.001	.001	3	11
STAD	Positive regulation of post-translational protein modification →	+0.046	+0.145	<.001	.001	3	10
STAD	Regulation of intrinsic apoptotic signaling pathway →	+0.084	+0.198	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,516 associations by consensus.

Regulation of protein serine/threonine kinase activity by TBXT expression — STAD

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