TBXT

Across TCGA pan-cancer cohorts, TBXT RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TBXT data layer compared with 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TBXT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TBXT expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

LUSC, LIHC, and STAD are the cancer types where TBXT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.604	0.732	<.001	107	view →
LIHC	DFS	Tertile	All	0.274	0.578	<.001	90	view →
STAD	DFS	Tertile	II,III,IV	0.533	0.737	<.001	83	view →
DLBC	OS	Tertile	III,IV	0.402	1.000	.011	38	view →
KIRC	DFS	Tertile	II,III,IV	0.252	0.544	.011	30	view →
BRCA	DFS	Tertile	III,IV	0.788	0.894	.003	24	view →
ACC	OS	Tertile	II,III,IV	0.310	0.729	.001	24	view →
HNSC	DFS	Quartile	All	0.145	0.463	.003	21	view →
UCEC	OS	Tertile	III,IV	0.754	0.858	.035	12	view →
COAD	DFS	Quartile	II,III,IV	0.768	0.626	.029	11	view →
KIRP	DFS	Tertile	All	0.812	0.931	.012	9	view →
THCA	DFS	Quartile	II,III,IV	0.841	0.928	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TBXT–LUSC (OS)

Open the LUSC breakdown →