TBXT

Across TCGA pan-cancer cohorts, TBXT RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TBXT’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where TBXT RNA is repressed in tumor relative to normal tissue. In most cancer types TBXT is over-expressed in tumor, although a few such as BRCA and READ show the opposite, repressed pattern.

BRCA, HNSC, and LUAD are the cancer types where TBXT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBXT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.084	<.001	6	view →
HNSC	All	All	+0.084	.008	5	view →
LUAD	Female	All	+1.071	<.001	4	view →
READ	Male	All	−0.106	.010	4	view →
LUSC	Male	II,III,IV	+0.031	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TBXT–BRCA

Open the BRCA breakdown →