TBXT

Across TCGA patient cohorts, TBXT mutation is significantly associated with the RNA expression of many other genes, with 1,958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBXT-associated genes across cancer lineages are RBPJP2, OR2M7, and MIR6792. Each is linked with TBXT in more than 2 cancer types. Because this analysis shows association rather than direction, both TBXT-to-partner and partner-to-TBXT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBPJP2 grouped by TBXT-low versus TBXT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBXT→partner) and Y-score (partner→TBXT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RBPJP2 →	+0.011	+2.884	<.001	.008	3	3
SCLC	OR2M7 →	+0.119	+5.624	<.001	.003	3	2
BRCA	MIR6792 →	+0.420	+5.971	<.001	.002	3	2
UCEC	ZNHIT3 →	+0.418	+2.480	.001	<.001	3	2
UCEC	TRBV12-4 →	+0.566	+2.565	<.001	.001	3	2
GBM	RNU6-166P →	+0.582	+6.614	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,958 associations by consensus.

RBPJP2 by TBXT expression — SKCM

Explore this box plot interactively →