TBXT

Across TCGA patient cohorts, TBXT mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBXT-associated genes across cancer lineages are FoxM1, C-Raf, and p70-S6K. Each is linked with TBXT in more than 2 cancer types. Because this analysis shows association rather than direction, both TBXT-to-partner and partner-to-TBXT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TBXT-low versus TBXT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBXT→partner) and Y-score (partner→TBXT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.208	+1.678	.036	.023	3	3
UCEC	C-Raf →	+0.168	+3.169	.002	.018	3	3
SKCM	p70-S6K →	-0.331	-2.321	.005	.035	3	2
UCEC	EGFR_pY1068 →	-0.299	-2.087	.001	.005	3	2
UCEC	STAT3_pY705 →	-0.375	-1.678	<.001	.023	3	2
SKCM	EGFR →	-0.184	-2.321	.023	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FoxM1 by TBXT expression — UCEC

Explore this box plot interactively →