TBXT

Across TCGA cell cohorts, TBXT mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBXT-associated genes across cancer lineages are TMIGD3, RTP2, and BAAT. Each is linked with TBXT in more than 1 cancer types. Because this analysis shows association rather than direction, both TBXT-to-partner and partner-to-TBXT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMIGD3 grouped by TBXT-low versus TBXT-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBXT→partner) and Y-score (partner→TBXT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TMIGD3 →	+0.075	+4.584	<.001	.001	3	1
LUNG_SCLC	RTP2 →	+0.021	+5.169	<.001	<.001	3	1
LARGE_INTESTINE	BAAT →	+0.406	+3.465	<.001	.002	3	1
LARGE_INTESTINE	MEAF6 →	+0.505	+3.067	.003	.009	3	1
LARGE_INTESTINE	FRMPD2 →	+0.393	+3.321	.005	.005	3	1
LARGE_INTESTINE	NRTN →	+1.147	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TMIGD3 by TBXT expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →