TBX5

Across TCGA patient cohorts, TBX5 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,594 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TBX5-associated proteins across cancer lineages are MFAP2, EFEMP1, and VCL_S346. Each is linked with TBX5 in more than 5 cancer types. Because this analysis shows association rather than direction, both TBX5-to-partner and partner-to-TBX5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TBX5 versus MFAP2 in OV, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX5→partner) and Y-score (partner→TBX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MFAP2 →	+0.962	+0.226	<.001	<.001	3	6
OV	EFEMP1 →	+0.762	+0.221	<.001	<.001	3	6
OV	VCL_S346 →	+0.766	+0.205	<.001	.001	3	5
BRCA	VIM →	+0.488	+0.649	<.001	<.001	3	5
LSCC	WDFY1 →	+0.258	+0.656	<.001	.001	3	5
OV	PRRX1 →	+0.703	+0.212	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,594 associations by consensus.

TBX5 vs MFAP2 — OV

Explore this scatter interactively →